Successful treatment of adult onset Langerhans cell histiocytosis with multi-drug combination therapy.
نویسندگان
چکیده
Adult onset Langerhans cell histiocytosis (LCH) is a rare disorder. Its clinical features have been well described in children, however remain poorly defined in adults. Optimal treatment strategy is still under debate. We have encountered two cases of adult onset LCH, which obtained a durable disease control by combination chemotherapy using prednisone, vinblastine and 6-mercaptopurine. Herein, we report their clinical features together with a review of the current literature.
منابع مشابه
Current Treatment Strategy in Langerhans Cell Histiocytosis
Langerhans cell histiocytosis (LCH) is a rare disorder described as three different entities including eosinophilic granulomaof bone, the Hand-Schuller-Christian syndrome, and Letterer-Siwe disease. LCH is currently classified into singlesystem LCH, and multisystem LCH. Patients with single system LCH have an excellent prognosis, and are mostlytreated with local therapy. Multisystem LCH is subd...
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BACKGROUND Langerhans cell histiocytosis (LCH) is a rare disease with a peak incidence in childhood. There is limited experience with treatment options for adult patients having multisystemic LCH involvement. We report successful treatment of a 70-year-old woman with adult onset of LCH and multisystem disease (diabetes insipidus centralis, bone marrow infiltration, and lung and skin involvement...
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© 2014 The Authors. doi: 10.2340/00015555-1807 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Langerhans cell histiocytosis (LCH) is characterised by the clonal proliferation of Langerhans cells (LC) that predominantly occurs in infants and small children, but LCH is rare in adults (1). Generally in children, local therapy would be an appropriate treatment, since patients...
متن کاملLangerhans Cell Histiocytosis in Childhood: Review, Symptoms in the Oral Cavity, Differential Diagnosis and Report of One Case
Background Langerhans cell histiocytosis (LCH) is a rare disease in which monoclonal migration and proliferation of specific dendritic cells is seen. The disease primarily affects the bones and skin, but there is a possibility that involves other organs or appears as a multi-systemic disease. Case Report In oral examination of a nine-month girl, two deep wounds with a yellow membrane with appro...
متن کاملLow-dose oral etoposide monotherapy in adult Langerhans cell histiocytosis.
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عنوان ژورنال:
- Internal medicine
دوره 50 8 شماره
صفحات -
تاریخ انتشار 2011